Table 4 Association between single-nucleotide polymorphisms (SNPs) in fetal SOD2 and MTHFR and risk for neural tube defects
| SNP and genotype | Controls [n (%)] | Cases [n (%)] | OR (95% CI) | P |
|---|---|---|---|---|
| SOD2 rs4880 | ||||
| AA | 104 (72.2) | 125 (80.6) | 1 | |
| AG | 35 (24.3) | 29 (18.7) | 0.69 (0.40–1.20) | 0.190 |
| GG | 5 (3.5) | 1 (0.6) | 0.17 (0.02–1.45) | 0.104 |
| P for trend | 0.045 | |||
| MTHFR rs1801133 | ||||
| CC | 24 (16.7) | 18 (11.6) | 1 | |
| CT | 78 (54.5) | 78 (50.3) | 1.33 (0.67–2.65) | 0.412 |
| TT | 41 (28.7) | 59 (38.1) | 1.92 (0.93–3.98) | 0.080 |
| P for trend | 0.059 | |||